Copper peptide GHK-Cu (glycyl-L-histidyl-L-lysine-copper) is a naturally occurring tripeptide with potent anti-aging properties that have made it a star ingredient in cosmetic formulations. Its unique combination of copper-binding and biological activity provides multiple benefits for skin health and appearance.
GHK-Cu was first identified in human plasma and has been studied for over four decades. It is naturally present in wound fluid and is involved in the wound healing process. The peptide's ability to bind copper is essential for its activity, as copper is a cofactor for enzymes involved in collagen synthesis, antioxidant protection, and tissue remodeling.
The biological activities of GHK-Cu include stimulation of collagen and elastin production, promotion of wound healing, antioxidant protection, and anti-inflammatory effects. Clinical studies have demonstrated that GHK-Cu reduces wrinkles, improves skin elasticity, and enhances skin firmness. It has also shown benefits for hair growth and wound healing.
GHK-Cu's mechanism of action involves multiple pathways. It upregulates the expression of growth factors and extracellular matrix proteins, promotes angiogenesis, and modulates inflammatory responses. These combined effects make GHK-Cu a versatile ingredient for addressing multiple signs of skin aging.
As a cosmetic ingredient, GHK-Cu is used in serums, creams, and other topical formulations. It is typically used at concentrations of 0.1-0.5% and is compatible with other active ingredients. At PeptideHub, we provide high-quality GHK-Cu for cosmetic formulation development, with appropriate purity and documentation for topical applications.